What's Your Problem?

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Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with entrepreneurs and engineers tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you…

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Episodes

New episodes usually drop on Thursdays.Latest 200 episodes in the feed

Oct 29, 2026 · 30 min

Every Cell in Your Body Has a Clock

Circadian rhythm isn’t just controlled by your brain. Every cell in your body runs on a 24-hour cycle, including your muscle cells.  Karyn Esser is the chair of the department of physiology and aging at the University of Florida, and she’s a leading expert on circadian rhythm in muscle cells. Karyn's problem is this: How does the circadian rhythm in muscle cells change as we age, and how does…
Oct 26, 2026 · 48 min

How a Bad Boss Kickstarted Silicon Valley... from Business History

Throughout the next few weeks, every Monday we'll be sharing some of our favorite episodes from Jacob's other show Business History. We hope you enjoy them and if you want to hear more, subscriber to Business History on Apple , Spotify or wherever you get your podcasts. William Shockley was an electronics genius - he even won a Nobel Prize - but he was an awful boss. Shockley was a cruel, paranoid micromanager. And…
Oct 22, 2026 · 40 min

Solving the Trust Problem in AI Shopping

Note: Today’s show is sponsored by PayPal. Kartik Hosanagar is a professor at the Wharton School. The problems he studies include: What will it take for people to trust AI agents to buy stuff for them? And how should businesses prepare for a world where their customers include AI agents? In this episode, Kartik explains: Why trust in agentic shopping will arrive category by category, not all at once How a…
Oct 15, 2026 · 50 min

Can a Robot Build Better, Cheaper Houses?

Jason Ballard is the co-founder and CEO of ICON. Jason's problem is this: Can you use 3-D printing to build houses that are cheaper, better and more interesting than the houses we build now? In this episode, Jason explains:  Why construction methods are so slow to change  How 3D printing opens up new designs for houses How building on the Moon shaped the way Icon builds on Earth The challenge of scaling…
Oct 8, 2026 · 38 min

Did AI Write This?

Celebrated novelists, countless students and at least one billionaire have recently been accused of using AI in their writing. The most commonly cited AI detector in these cases is called Pangram.  Max Spero is the co-founder and CEO of Pangram. His problem is this: Can you build tools that reliably detect AI-generated text and images? And a few years from now, will anybody care? In this episode, Max…

Earlier episodes (195)

Oct 6, 2026 Blockers | A Preview of Michael Lewis's New Audiobook
I'm here with a preview of Blockers, a new audiobook from Michael Lewis, the author of Liars Poker, Moneyball, The Big Short and more. In Blockers, Lewis tells the story of a handful of people who dedicated their careers to public service—until the Department of Government Efficiency decided they were a problem. These were people who believed they had a calling—people who kept American's sensitive tax…
Oct 1, 2026 Can We Defeat Deepfakes?
We’ve all heard that nothing ever gets deleted from the internet. Luke Arrigoni says that just isn’t true. His company deletes thousands of deepfakes every day. Luke is the founder and CEO of Loti, and his problem is this: How do you turn the Internet into a place where people have more control over their name, image and likeness? Tens of thousands of famous people pay Loti to scour the internet and…
Sep 24, 2026 The Printing Press: The Invention Built on Debt and Sin… from Business History
Before 1450, books were written out by hand. It was slow and expensive. But Johannes Gutenberg borrowed a ton of money to create a printing press that could crank out Bibles and pamphlets and documents in huge numbers. Science, politics and philosophy were all up-ended.  For example, the Catholic Church seized on the invention to sell special certificates absolving people of their sins – a move that made…
Sep 17, 2026 Should We Pause AI?
Everybody’s worried about the risks of AI. So we called up one of the most insightful writers we know on the subject: Zvi Mowshowitz. Zvi writes about AI and AI risks at his substack, Don’t Worry About the Vase . Zvi’s problem is this: How do we prevent artificial intelligence from killing everyone?  In this episode, Zvi explains:  Why it’s often useful to anthropomorphize AI …
Sep 15, 2026 Bonus: Planning for Your Financial Future
On this bonus episode of What’s Your Problem, Jacob talks to Christine Chase, a Vice President, Financial Consultant at Fidelity Investments. Christine’s problem is this: How do you help clients build a plan to achieve their financial goals? Today’s show is sponsored by Fidelity Investments. See omnystudio.com/listener for privacy information.
Sep 10, 2026 Can a Robot Kill Fish Humanely?
The fish we eat usually die slowly, suffocating after they’re pulled out of the water. Saif Khawaja is the co-founder and CEO of a company called Shinkei. Saif's problem is this: Can he build a machine to efficiently kill fish in a way that is more humane? In this episode, Saif explains:  How he came to believe that our current fishing practices are inhumane  How he adapted the Japanese technique of…
Sep 3, 2026 Using Satellites to Prevent Famines
Catherine Nakalembe is an assistant professor at the University of Maryland and the head of the Africa program at NASA Harvest, which uses satellite images to track agriculture around the world. Catherine’s problem is this: How do you predict when a famine is coming – and how do you convince leaders to act in time? In this episode, Catherine explains:  How satellite data can predict crop failure…
Aug 20, 2026 The Quantum Shift in Biomedical Discovery from Smart Talks with IBM
When Dr. Lara Jehi began treating epilepsy patients in the 2000s, critical surgical decisions were driven more by clinician intuition and expertise than data. Today, she is a leader of IBM and Cleveland Clinic’s Discovery Accelerator, using advanced AI and quantum computing to transform how researchers analyze data, simulate molecules, accelerate drug discovery, and develop more precise treatments. Malcolm…
Aug 13, 2026 Can We Slow Down Aging?
Nir Barzilai is a physician and a researcher at the Albert Einstein College of Medicine in New York, where he runs the Institute for Geroscience. Nir’s problem is this: How can we use lifestyle changes and drugs to slow the process of aging? In this episode, Nir explains:  The search for biological markers of aging The existing drugs that might reduce the risk of diseases associated with aging The four…
Aug 6, 2026 Why Doctors Use Evidence but Managers (Mostly) Don’t
Helen Pearson is the author of the book “Beyond Belief: How Evidence Shows What Really Works.” Helen's problem is this: How do you get people to make important decisions based on high-quality evidence, instead of on hunches or habits? In this episode, Helen explains:  How a doctor's fatal mistake sparked the evidence-based medicine movement Why management is so resistant to evidence-based practices…
Jul 30, 2026 The Job AI Was Supposed to Kill
In 2016, Geoffrey Hinton, one of the inventors of modern AI, predicted that AI would replace radiologists within years. Ten years later, we have a shortage of radiologists. AI has yet to revolutionize the field. What happened, and what does the story of AI and radiology tell us about AI and the future of work? Saurabh Jha is a radiologist at the University of Pennsylvania. He's written about how he uses AI in his…
Jul 23, 2026 How China Won the Car Industry
After spending decades as marginal players in the global auto industry, Chinese carmakers have become the world’s biggest exporters of cars. Chinese cars are some of the best cars on the planet, and they’re available almost everywhere – except in the US. Michael Dunne is the CEO of Dunne Insights, a company that consults on the future of cars. Michael has been working with the Chinese auto…
Jul 16, 2026 Using Viruses to Fight Disease
Phages are viruses that attack bacteria. People have been using phages to treat infections for over a hundred years, but in most cases they just don't work as well as antibiotics.  Paul Garofolo is the co-founder and CEO of Locus Biosciences. His problem is this: How do you genetically engineer phages to be more effective at curing disease?  In this episode, Paul explains:  Why wild phages never…
Jul 9, 2026 How AI Could Reduce Inequality
David Autor is a labor economist at MIT. He has written about how the arrival of personal computers increased inequality among American workers. But when it comes to AI, David thinks there could be a different outcome.  Read David’s article about AI in Noema Magazine .  In this episode, David explains:  How computers increased the wage gap between college and non-college educated workers Why…
Jul 2, 2026 Racing Wildfires to Warn the Public
John Mills is the CEO and co-founder of a nonprofit called Watch Duty. His problem is this: How do you build an app to warn people when they are in immediate danger from a natural disaster? Watch Duty has millions of users and played a key role in the Los Angeles fires of 2025. In the show, John talks about how he built his app with the help of an army of volunteers, and why the government hadn’t already…
Jun 25, 2026 How AI Could Actually Make the World Better
Josh Tyrangiel is the author of “ AI for Good: How Real People Are Using Artificial Intelligence to Fix Things That Matter .” On today’s show, Josh talks about some of these real people and the problems they’re working on: a professor trying to understand her nonverbal son, a general who delivered millions of Covid vaccines in 2021, and a hospital CEO trying to reduce the rate of deadly…
Jun 18, 2026 Finding Meaning (and Money) in the AI Age
Betsey Stevenson is a labor economist at the University of Michigan, and she was an economic adviser to President Obama. Betsey’s problem is this: How can we create a world where the benefits of AI are broadly shared? Betsey draws on history – including how the invention of household appliances created a crisis of meaning for American women – to understand how we should respond to the challenge of…
May 28, 2026 Using Pokémon Go to Map the World
Maps have gotten much better over the past few decades. But they're still mostly two dimensional, and they struggle to keep up with a world that is always changing. Brian McClendon is the Chief Technology Officer of Niantic Spatial, a spinout of the company that makes Pokémon Go. Brian's problem is this: How do you build a three-dimensional map of the world that both robots and humans can use to find their…
May 21, 2026 The Company Where Everyone Has Their Own AI Agent
Dan Shipper is the co-founder and CEO of Every, a company that publishes newsletters about AI, develops AI-related software, and helps other companies use AI. Dan has two problems. One, how do you build a company where almost everybody has their own AI agent? And two, how do you use AI as a tool to improve your writing, rather than as a replacement for writing? In this episode, Dan explains:  Why managing…
May 14, 2026 Inventing a Better Apple
The apples you can buy at the grocery store have gotten profoundly better over the past few decades. It’s a kind of everyday, hiding-in-plain sight innovation. Kate Evans is an apple breeder and professor at Washington State University. Kate's problem is this: How do you invent a better apple? With her team, Kate has in fact invented a new kind of apple called the Sunflare. It’s arriving in stores in a…
May 7, 2026 Building a Business on the Moon
Rob Meyerson is the co-founder and CEO of Interlune. Rob's problem is this: How do you help build an economy on the moon? Eventually, Rob hopes Interlune will help build a moon base. For now, he is focused on bringing a gas called helium-3 back from the moon to sell on earth.  Earlier in his career, Rob was the president of Blue Origin, the rocket company founded by Jeff Bezos. In this episode, Rob…
Apr 30, 2026 Building a Robot People Actually Want
Aaron Edsinger left his job as director of robotics at Google to start a company called Hello Robot. Aaron’s problem is this: How do you build an affordable robot that people can use to solve real problems at home? The result is a robot that looks nothing like a person. In fact, it’s closer to a Roomba with an arm. In this episode, Aaron explains:  Why home robots have barely progressed since the…
Apr 23, 2026 Turning Waste Wood Into Buildings
Ben Christensen is the co-founder and CEO of Cambium, the largest seller of salvaged wood in America. Ben's problem is this: How can we turn the trees that are falling to the ground all around us, into usable wood? In this episode, Ben explains:  Why so much wood goes unused  Why Cambium created demand before building the supply chain  How building a data layer across the fragmented lumber industry…
Apr 16, 2026 The Great Fusion Debate: How Far Away Are We Really?
Investors are pouring billions of dollars into nuclear fusion companies. The dream: transform human civilization (and power AI data centers) by providing cheap, abundant energy. But nobody’s figured out how to make it work yet. What will it take to make fusion work at scale – and how will the world be different if it does? To answer this question, Jacob recently hosted a conversation at SXSW between…
Apr 9, 2026 How SharkNinja Keeps Going Viral
Mark Barrocas is the CEO of SharkNinja, a company that sells everything from vacuums, to blenders, to beauty products. Mark’s problem is this: How do you invent new products that people want to rave about on social media?  In this episode, Mark explains:  How SharkNinja finds product ideas The tradeoffs at the heart of product development How the Ninja Creami became a viral hit Why some products…
Mar 19, 2026 Growing New Livers to Save Lives
Michael Hufford is the co-founder and CEO of LyGenesis, a company working on a new treatment for end stage liver disease. Michael’s problem is this: How do grow a new liver inside the body of a sick patient? In this episode, Michael explains:  The liver's unique power of regeneration The organ transplant crisis and how regeneration can help  The science behind using lymph nodes to grow new organs…
Mar 12, 2026 Can the US Break China's Grip on Rare Earths?
Rare earth elements are inside pretty much everything with an on-off switch: Phones, laptops, cars. Even missiles. And China controls the world’s supply of components made from rare earths. David Abraham is the author of the book “ The Elements of Power: Gadgets, Guns, and the Struggle for a Sustainable Future in the Rare Metal Age .” David’s problem is this: What should the US do about…
Mar 5, 2026 How Quantum Computers Could Change the World
Ben Bloom is the co-founder and CEO of Atom Computing, a company building quantum computers out of individual atoms. Ben’s problem is this: How do you build a quantum computer that is actually useful for everything from discovering new medicines to building better batteries?  In this episode, Ben explains:  The practical applications of quantum computers  Atom Computing’s approach using…
Feb 26, 2026 Fighting Wildfires from Space
Jonny Dyer is the founder and CEO of a satellite company called Muon Space . The company’s first big project is a satellite constellation called FireSat. Jonny’s problem is this: How do you capture data from space to help manage wildfires around the world in near-real time?  In this episode, Jonny explains: How smartphone tech inspired smaller, cheaper satellites. Why fighting wildfires is still…
Feb 19, 2026 The Killer We Refused to See
After bacteria were discovered, it took scientists 200 years to figure out that they cause disease. If scientists had made the link sooner, hundreds of millions of lives could have been saved.  In his recent book So Very Small, Tom Levenson, a professor of science writing at MIT, tells the amazing story of germ theory, and argues that our worldview can prevent us from seeing what is right in front of us…
Feb 12, 2026 The Startup Run by AI Agents
Evan Ratliff co-founded a publishing startup in 2011. Now he hosts a podcast called Shell Game. In the latest season of the show, Evan creates a company run by AI agents. The project is absurdly funny – Evan calls it an office satire – but it also illuminates the power and limits of AI agents. See omnystudio.com/listener for privacy information.
Feb 5, 2026 Can AI Help Solve Alzheimer’s?
Patrick Hsu is the co-founder of Arc Institute, which is integrating AI models and biological research. Patrick’s problem is this: How can you use AI to make biological research more efficient – and ultimately to find cures for Alzheimer’s and other complex diseases? See omnystudio.com/listener for privacy information.
Jan 29, 2026 The New Science of Preventing Heart Attacks
In recent decades, medical research has fundamentally changed how we think about heart disease. This fresh understanding has opened up new ways to prevent heart attacks. Eric Topol is a cardiologist and the founder of the Scripps Research Translational Institute in San Diego. Eric’s problem is this: How can doctors use recent technological developments to do a better job at preventing heart attacks? See…
Jan 22, 2026 From Solar Pumps to Everything: Building a Market from Scratch
Samir Ibrahim is the co-founder and CEO of SunCulture. When he started the company, he thought he was solving a simple problem: How do you sell solar-powered pumps to help poor farmers irrigate their land? It turned out, he was working on something much bigger: How do you help poor farmers get richer, and create a giant new market from scratch? See omnystudio.com/listener for privacy information.
Jan 15, 2026 Mass-Producing Stem Cells to Cure Disease
Nabiha Saklayen is the co-founder and CEO of Cellino. Nabiha’s problem is this: How can you make personalized stem cell therapies quickly and cheaply? Induced pluripotent stem cells, or IPSCs, have shown tremendous promise as treatments for illnesses like Parkinson’s, leukemia, and heart disease. On today’s show, Nabiha explains why IPSC manufacturing is still mostly done by hand, how her…
Dec 18, 2025 Building a Self-Driving Tractor to Change the Future of Food
Please take our survey https://tinyurl.com/wyplistenersurvey  about the show! Tell us what you want to hear, and what would make it better. Tim Bucher is a farmer, and the founder and CEO of Agtonomy. Tim's problem is this: How do you build an autonomous tractor that can work for specialty crops like grapes, olives, apples, and almonds?  On today’s show, Tim explains what makes certain farming…
Dec 11, 2025 We’re Going to Need a Better Boat
Mitch Lee is the co-founder and CEO of Arc Boats. Mitch's problem is this: How do you build competitively priced electric boats? On today’s show, Mitch explains why water makes electrification so hard, the techno-economic puzzle of building giant battery packs, and how Arc’s high-end wake sport boat opened the door for a new generation of hybrid-electric tugboats. See omnystudio.com/listener for privacy…
Nov 20, 2025 The App Where Strangers Lend Each Other Money
Nina Mohanty is the founder and CEO of Bloom Money. Nina’s problem is this: How do you build an app to help immigrants manage their money? On today’s show, Nina talks about bringing a saving and lending practice into the 21st century, navigating regulators who’ve never seen anything like it, and what global traditions can teach us about the future of money. See omnystudio.com/listener for privacy…
Nov 18, 2025 Introducing Business History: The Edison Invention People Don't Talk About
What's Your Problem? host Jacob Goldstein has a new show: Business History . How did Hitler’s favorite car become synonymous with hippies? What got Thomas Edison tangled up with the electric chair? Did someone murder the guy who invented the movies? On Business History, Jacob and fellow former Planet Money host Robert Smith examine the surprising stories of businesses big and small and find out what you can…
Nov 13, 2025 Using Sound Waves to Destroy Tumors
Mike Blue is the CEO of HistoSonics. The company recently developed a device that uses ultrasound to destroy tumors. On today’s show, Mike talks about how a garage-built prototype became an FDA-approved machine; changing the company’s story after a failed clinical trial; and why he loves being a salesman but hates most sales pitches. See omnystudio.com/listener for privacy information.
Nov 6, 2025 From Desert Robots to Driverless Trucks
Chris Urmson is the co-founder and CEO of Aurora, a company trying to bring autonomous driving to commercial trucking. Chris led a team at the 2004 DARPA challenge that launched the autonomous vehicle industry. Then he held a senior role at Google’s self-driving car project, which later became Waymo. On the show today, he talks about the long arc of autonomous driving, why he left Google, and the future of…
Oct 30, 2025 Is the Future of Fresh Water Under the Sea?
Michael Porter is the Chief Technology Officer of OceanWell. Michael's problem is this: How can you desalinate water at the bottom of the ocean – and deliver it to land at a cost that’s competitive with other sources of fresh water? On today’s show, Michael explains how he built OceanWell’s prototype in his kitchen, what it takes to make a system that’s less disruptive to marine life,…
Oct 23, 2025 Could Home Batteries Save the Grid?
Justin Lopas is the COO and co-founder of Base Power, a battery and power company based in Texas. Justin’s problem is this: How can you deliver more energy to more people without having to build so much more grid? On today’s show, Justin explains why the grid needs a major upgrade, and how putting batteries next to homes could help. Also: what Texas’ embrace of renewable energy could mean for the…
Oct 16, 2025 Building a Better Public Bathroom
Fletcher Wilson is the CEO and co-founder of Throne Labs. Fletcher’s problem is this: How can you create public toilets that people actually want to use? On today’s show, Fletcher explains how his company is trying to make public bathrooms cleaner, safer and more accessible. The conversation also points to a bigger idea: why it’s so hard for cities to build and maintain pretty much anything. See…
Oct 2, 2025 Could Autonomous Diggers Unleash a Building Boom?
Boris Sofman is the co-founder and CEO of Bedrock Robotics. Boris' problem is this: How do you teach machines not just to drive, but also to work: to grade roads, move heavy objects and dig big holes at construction sites. On today’s show, Boris talks about how his work at Waymo led him to found Bedrock, and he explains how autonomous construction equipment could help unleash an American building boom. See…
Sep 25, 2025 Growing Meat from Cells
Justin Kolbeck is the co-founder and CEO of Wildtype, a company making seafood without killing fish. Their first product is cultivated salmon, which is made from real salmon cells that are grown in a stainless steel vat. Justin's problem is this: How to sell no-kill, vat-grown salmon for the same price, or better, as wild-caught salmon? On today’s show, Justin explains how Wildtype will scale, what’s…
Sep 18, 2025 The Ordinary Stuff Behind Technological Breakthroughs
Ed Conway is an economics journalist and author of the book “Material World: The Six Raw Materials that Shape Modern Civilization.” On today’s show, Ed reveals how three of those often-overlooked materials—iron, copper, and sand—shaped human advancement from the Renaissance to the Industrial Revolution to the digital age. And he talks about what they mean for our future. See…
Sep 11, 2025 Carbon Capture at Rock-Bottom Prices
Shashank Samala is the CEO and co-founder of Heirloom, a carbon capture start-up. His problem is this: Can you use crushed up rocks to permanently suck carbon out of the atmosphere? And can you do it cheaply enough to have a global impact? On today’s show, Shashank explains why he believes rocks could be the backbone of carbon capture, how his childhood in India shaped his outlook on climate change, and how…
Sep 4, 2025 Why Amazon Built a Spatula-Wielding Robot
Aaron Parness is a director of applied science at Amazon Robotics. His problem is this: How do you build a robot that can put stuff on shelves. Today on the show, Aaron explains why this is a surprisingly hard problem – and why the solution Aaron’s team came up with may ultimately have uses beyond the warehouse. See omnystudio.com/listener for privacy information.
Aug 28, 2025 Drilling Smarter Wells to Unleash Geothermal Energy
In many places on Earth, there’s steam just below the surface. We don’t know where those places are — but if we could figure it out, we could unlock a lot of clean energy. Carl Hoiland is the co-founder and CEO of Zanskar, a geothermal energy company. On today’s show, Carl makes the case for geothermal in the energy transition and explains how the company is developing new ways to identify…
Aug 21, 2025 Inventing a Better Pain Pill
Dr. Stephen Waxman is a professor of neurology, neuroscience and pharmacology at Yale. His research on pain helped pave the way for a newly approved, non-addictive pain drug called suzetrigine. On today’s show, he explains why he thinks suzetrigine is a promising step, but why much more work is needed to develop better pain drugs. He also gets into his work on ion channels—critical to unlocking the pain…
Aug 14, 2025 Mapping the Unmappable
Philipp Kandal is the chief product officer of Grab, an app that serves several countries across Southeast Asia. Two of Grab’s main businesses are delivery and mobility – like a combination between Instacart and Uber. And maps are at the core of its business. On today’s show, Philipp talks about improving online maps for places like Southeast Asia, where streets are often winding, narrow, and…
Aug 7, 2025 Reinventing Blood
Dr. Allan Doctor is the co-founder and chief scientific officer at Kalocyte, a company that is developing dried red blood cells that can be rehydrated and used in medical emergencies. On today’s show, Dr. Doctor explains the complex science behind artificial blood, and how this innovation could help save millions of lives. See omnystudio.com/listener for privacy information.
Jul 17, 2025 The AI Pioneer Developing New Kinds of Medicine
Jakob Uszkoreit is the CEO and co-founder of Inceptive, a biotech start-up. He’s also a co-author of “Attention is All You Need,” the paper that created transformer models. Today, transformers power chatbots like ChatGPT and Claude. They’ve also led to breakthroughs in everything from generating images to predicting the structure of proteins. On today’s show, Jakob talks about the…
Jul 10, 2025 A Billion-Dollar Bet on Carbon Removal
Nan Ransohoff is the head of climate at Stripe. The company is known mainly for facilitating online payments, but it’s become a key driver of the nascent carbon-removal industry. On today’s show, Nan explains how she used a clever economic idea to get companies to spend $1 billion on carbon removal. And she talks about the different approaches startups are pursuing to pull carbon dioxide out of the…
Jul 3, 2025 Giving Old Batteries New Life
Megan O’Connor is the co-founder and CEO of Nth Cycle. Megan’s problem is this: How do you create a new system that can both refine the raw metals we need for new batteries and recycle metal from old batteries? See omnystudio.com/listener for privacy information.
Jun 26, 2025 Engineering the Future of Fusion
Getting energy from nuclear fusion has been a dream for decades; it would be cheap, abundant, and safer than today’s nuclear fission reactors. Billions of dollars have flowed into fusion startups in recent years, but reliable, economic fusion power may still be decades away. Greg Piefer is the founder of a fusion company called Shine , where he’s pursuing a different path. Rather than go straight to…
Jun 19, 2025 Can Robots Fix Recycling?
Recycling plants take in a huge amount of random (and occasionally hazardous) stuff, which they then have to turn into reliable outputs that their customers will buy. That’s why Rebecca Hu Thrams calls recycling “the most demented form of manufacturing on the planet.” Rebecca is the co-founder of Glacier, and her problem is this: Can you use AI and robots to make recycling a somewhat less demented…
Jun 12, 2025 Inside the Mind of an AI Model
AI might be the most consequential advancement in the world right now. But – astonishingly – no one fully understands what’s going on inside AI models. Josh Batson is a research scientist at Anthropic, the AI company behind Claude, one of the world’s leading language models. Josh’s problem is this: How do we learn how AI works? Get early, ad-free access to episodes of What's Your…
Jun 5, 2025 Teaching Robots How to Do Everything
AI is better than humans at a lot of things, but physical tasks – even seemingly simple ones like folding a shirt – routinely stump AI-powered robots. Chelsea Finn is a professor at Stanford and the co-founder of Physical Intelligence. Chelsea's problem is this: Can you build an AI model that can teach any robot to do any task, anywhere? Get early, ad-free access to episodes of What's Your Problem? by…
May 29, 2025 Making a Universal Flu Vaccine
Jacob Glanville is the founder and CEO of Centivax. Jacob’s problem is this: Can you create a vaccine that protects people against almost all strains of flu – even strains that haven’t evolved yet? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive…
May 22, 2025 Teaching Computers to Smell
Alex Wiltschko got obsessed with perfume when he was 12 years old. He grew up to be an AI researcher at Google. Then he started Osmo, a company that fused his job at Google with his childhood obsession: Osmo is using AI to teach computers to smell. The company is getting into the perfume business, and it plans eventually to use scent to diagnose disease and detect security risks. Get early, ad-free access to…
Apr 24, 2025 Can a Chatbot Treat Depression?
Nick Jacobson and his team at Dartmouth medical school spent over 100,000 hours trying to build an AI chatbot that can serve as a safe, effective therapist. After a few false starts, they seem to be on to something. Note: This episode contains references to self harm. Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can…
Apr 23, 2025 Will AI Radically Change the World by 2027?... from Risky Business
This week, Nate and Maria discuss AI 2027, a new report from the AI Futures Project that lays out some pretty doom-y scenarios for our near-term AI future. They talk about how likely humans are to be misled by rogue AI, and whether current conflicts between the US and China will affect the way this all unfolds. Plus, Nate talks about the feedback he gave the AI 2027 writers after reading an early draft of their…
Apr 17, 2025 Is the Future of Flight Supersonic?
Blake Scholl is the founder and CEO of Boom Supersonic. Blake's problem is this: Can you build a commercial airplane that flies faster than the speed of sound – and that makes economic sense? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus…
Apr 10, 2025 The Secrets of Silk
Fiorenzo Omenetto is a professor of biomedical engineering at Tufts University and the director of Silklab. Fiorenzo's problem is this: How do you turn a material people have been using for thousands of years into useful, cutting edge tools that improve everything from vaccine delivery to food waste? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or…
Apr 8, 2025 Infiltrating an International Ransomware Gang
A few years ago, a ransomware gang called LockBit rose from obscurity to extort over $100 million from organizations around the world. A security strategist named Jon DiMaggio wanted to understand how the organization worked. So he used the techniques of World War II-era spycraft to make contact with the hackers. On today’s show, Jon tells the story of LockBit – from the way it borrowed techniques from…
Apr 3, 2025 Preparing for the Future of War
Christopher Kirchhoff helped launch a Defense Department office that aimed to bring Silicon Valley technology to the US military. Christopher’s problem is this: How can the giant bureaucracy that is the US military keep up with technological change? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free…
Mar 13, 2025 Stopping HIV Without a Vaccine
Jared Baeten is senior vice president in virology at Gilead Sciences. Jared's problem is this: In a world without a vaccine, how do you make a medicine that people will actually take to help prevent HIV? There’s already a daily pill that reduces the risk of getting HIV, but a majority of people who are at high risk are unwilling or unable to take it. So Jared and his colleagues are developing a new drug,…
Mar 6, 2025 Harnessing the Heat Deep Beneath Our Feet
Carlos Araque is the co-founder and CEO of Quaise Energy. Carlos' problem is this: How do you make drilling for geothermal energy as routine, widespread, and profitable as drilling for oil or gas? The answer involves digging deeper into the Earth than anyone has ever dug before. See omnystudio.com/listener for privacy information.
Feb 27, 2025 The Brain Implant That Could Change Medicine
Ben Rapoport is the co-founder and CSO of Precision Neuroscience. Ben's problem is this: Can you build a device that allows a paralyzed person to use a computer with only their thoughts – without damaging their brain? See omnystudio.com/listener for privacy information.
Feb 20, 2025 Building a Mass Market Robot
Jeff Cardenas is the co-founder and CEO of Apptronik. Jeff's problem is this: Can you make a safe, reliable humanoid robot – for less than $50,000? In the short term, Apptronik’s robots will work in factories. But Jeff’s long-term goal – based on the experience of his own grandparents – is to build robots that can help care for the elderly. See omnystudio.com/listener for privacy…
Feb 13, 2025 Solving Solar’s Biggest Problem
We need better, cheaper ways to store solar and wind energy when it’s dark out and the wind isn’t blowing. One option: Compressing air in underground caverns when energy is abundant, then blowing it back out to create energy when you need it. It’s an old idea, but it has some fundamental problems. Curtis VanWalleghem, the co-founder and CEO of Hydrostor, thinks his company has solved those…
Feb 6, 2025 How Bubbles Power Breakthroughs
There are moments in history when people make huge technological advances all of a sudden. Think of the Manhattan Project, the Apollo missions, or, more recently, generative AI. But what do these moments have in common? Is there some set of conditions that lead to massive technological leaps? Byrne Hobart is the author of a finance newsletter called The Diff, and the co-author of Boom: Bubbles and the End of…
Jan 30, 2025 Teaching AI to Build Stuff in the Physical World
AI works well in the virtual world. That’s partly because the internet provides so much data to train AI models. But there’s no analogous data set for the physical world – and as a result, AI doesn’t work as well there… yet. Edward Mehr is the co-founder and CEO of Machina Labs. Edward's problem is this: How can you use AI to turn robots from dumb, inflexible machines into skilled,…
Jan 23, 2025 NVIDIA: At the Heart of the AI Boom
In the past few years, NVIDIA has become one of the most valuable and important companies in the world by making GPUs, the chips powering the AI boom. But where did the company come from, and why are NVIDIA chips the ones that dominate AI? Tae Kim is the author of a new book called The Nvidia Way. In his book, he tells the story of how NVIDIA’s founder and CEO, Jensen Huang, set NVIDIA on the path to becoming…
Jan 16, 2025 What Claude Shannon Figured Out
Claude Shannon is a major figure in the history of technology. Known as the father of information theory, Shannon spent decades at Bell Labs and MIT. But what exactly did Claude Shannon figure out, and why is it so important? To answer that question, Jacob talked with David Tse, a professor of electrical engineering at Stanford who studied under one of Shannon’s students, and who teaches Shannon to his own…
Dec 19, 2024 Measles: The Cancer Killer?... from Incubation
We thought we knew everything there was to know about measles. But in recent years, new research has revealed that the virus attacks the immune system and creates effects far more dramatic than a rash and fever. For this episode we’re joined by Michael Mina, a former Harvard epidemiologist now at eMed, who helped discover how measles was causing “immune amnesia.” Our second guest is Stephen…
Dec 12, 2024 RoboPod and the Perpetual Money Machine – Cautionary Questions 2… from Cautionary Tales
What really drove the 2008 financial crash? What’s a shadow bank? And what’s the connection between NIMBYs and BANANAs? Tim Harford and Jacob Goldstein answer more of your questions. Enjoy this episode from Cautionary Tales , another Pushkin Podcast. See omnystudio.com/listener for privacy information.
Dec 2, 2024 Turning Solar Energy Into Fuel (The Solar Era, Part 3)
Solar power and batteries are becoming cheap and ubiquitous. Great. But there are problems batteries can’t solve – like fueling ships and planes. One way to solve those problems: Use solar power to create hydrogen, and turn that hydrogen into fuel. Today’s guest is Raffi Garabedian, the co-founder and CEO of Electric Hydrogen. Raffi’s problem is this: How do you turn solar and wind energy into clean hydrogen that’s…
Nov 28, 2024 Can Hot Bricks Save the World? (The Solar Era, Part 2)
This is the second of three episodes about the solar-power revolution. Last week, we talked about how solar power got so cheap. This week, we’re talking with someone who is building giant plants around the world to take advantage of all that cheap, intermittent energy. John O'Donnell is the co-founder of Rondo Energy. John’s problem is this: How do you turn intermittent energy into the cheap, reliable, intense heat…
Nov 21, 2024 How the Sun Won (The Solar Era, Part 1)
In the past 20 years, the price of solar panels has fallen by more than 97 percent. This extraordinary decline is good news for the world – and it’s transforming the way energy is produced and consumed. For the next few episodes, we’ll be talking to people who are in the middle of this solar power revolution to find out how it happened, and what it will mean for the world. Today, Jenny Chase, the author of Solar…
Nov 14, 2024 Drugs in Space
Paul Reichert is a research scientist at Merck, working on improvements to how we administer drugs to patients. Paul's problem is this: How can you run experiments in space to learn how to make better drugs on Earth? See omnystudio.com/listener for privacy information.
Nov 7, 2024 The World Is Getting Better (Really)
Hannah Ritchie is a data scientist and the deputy editor of Our World in Data. She is also the author of Not the End of the World: How We Can Be the First Generation to Build a Sustainable Planet. Hannah’s problem is this: How do you use data to get past the doomsday headlines and solve big problems to achieve sustainability? Check out Our World in Data: https://ourworldindata.org/ See omnystudio.com/listener for…
Oct 31, 2024 Rabies: When Monsters are Real…from Incubation
Why has rabies invaded our nightmares for centuries? Author and veterinarian Monica Murphy tells us about the cultural history of rabies (which involves vampires and werewolves!) and how our long nightmare with the disease came to an end. Then, wildlife biologist Kathy Nelson tells us about a surprising program that works to control raccoon rabies… from the sky. Enjoy this episode from Incubation , another Pushkin…
Oct 17, 2024 Using Gene Therapy to Help the Blind See
After decades of research, gene therapy is starting to work. Shannon Boye is a professor of cellular and molecular therapeutics at the University of Florida. She is also the co-founder and chief scientific officer of Atsena Therapeutics. Shannon’s problem is this: How do you use gene therapy to cure certain forms of blindness? See omnystudio.com/listener for privacy information.
Oct 10, 2024 Bringing Back Mammoths and Dodos*
*Or at least, sort of bringing back mammoths and dodos. Beth Shapiro is the chief scientific officer at Colossal Biosciences and the author of How to Clone a Mammoth: The Science of De-Extinction. Beth's problem is this: How do you use the tools of modern biology – and hundreds of millions of dollars – to bring back species that have been extinct for centuries? And on another level, Beth’s problem is explaining to…
Oct 3, 2024 What Elevators Teach Us About Technology, Design, and Human Behavior
The elevator made the modern city possible: No elevators, no skyscrapers. Today, people are working on entirely new kinds of elevators that can go higher and faster than ever. On today’s show, we talk about those innovations with Lee Gray, who is possibly the world’s leading elevator historian and definitely a professor of architectural history at the University of North Carolina at Charlotte. See…
Sep 26, 2024 Can the Plant Microbiome Revolutionize Farming?
The invention of synthetic fertilizer was one of the key breakthroughs of the 20th century. It’s the reason we can grow enough food to feed billions of people. It’s also super energy intensive. Karsten Temme is the co-founder and Chief Innovation Officer at Pivot Bio. Karsten's problem is this: How can you use the tools of gene editing to get microbes in soil to provide more nitrogen for crops? See…
Sep 19, 2024 Turning Pollution into Jet Fuel
Jennifer Holmgren is the CEO of LanzaTech. Her problem is this: How do you capture pollution from factories, feed it to bacteria, and get the bacteria to produce ethanol, which can become everything from polyester to jet fuel? See omnystudio.com/listener for privacy information.
Sep 12, 2024 Reinventing Mining to Power the World
Moving from fossil fuels to renewable energy will require huge amounts of copper, lithium, and other metals. Kurt House is the co-founder and CEO of KoBold Metals. The company recently made a huge copper discovery in Zambia, and is looking for other metals in other places. Kurt's problem is this: How do you use AI – machine learning, data science – to find the metals we'll need for the energy transition? See…
Sep 5, 2024 Inventing a Vaccine for Bees
Dalial Freitak and Annette Kleiser are the co-founders of Dalan Animal Health, a company that has brought to market the first vaccine for insects. Their problem is this: How do you turn a discovery about insect immune systems into a vaccine that can protect the bees we need to grow everything from almonds to blueberries? See omnystudio.com/listener for privacy information.
Aug 29, 2024 A Better Way to Make the Chemicals in Everything
Sean Hunt is the co-founder and CTO of Solugen, a company that sells around $100 million a year of industrial chemicals. Sean's problem is this: How do you make the chemicals that go into everything around us -- our food, our clothes, our cars -- without using fossil fuels? See omnystudio.com/listener for privacy information.
Aug 8, 2024 How Refrigeration Changed the World
Refrigeration is an underrated technology. It completely transformed what billions of people eat every day. Today’s guest, Nicola Twilley, tells the story of refrigeration in her new book, Frostbite: How Refrigeration Changed Our Food, Our Planet, and Ourselves. Topics under discussion include: Why brewers were key drivers of refrigeration technology; the extraordinary technology inside a bag of lettuce; and why…
Aug 1, 2024 Detecting Deepfakes With AI
As generative AI tools improve, it is becoming easier to digitally manipulate content and harder to tell when it has been tampered with. Today we are talking to someone on the front lines of this battle. Ali Shahriyari is the co-founder and CTO of Reality Defender. Ali's problem is this: How do you build a set of models to distinguish between reality and AI-generated deepfakes? See omnystudio.com/listener for…
Jul 25, 2024 Turning Old Cans Into Clean Energy
Aluminum is the most abundant metal in the Earth’s crust. It’s cheap, ubiquitous, and surprisingly energy dense. Peter Godart is the co-founder and CEO of Found Energy. Peter's problem is this: How can you use aluminum as a source of clean, renewable energy? See omnystudio.com/listener for privacy information.
Jul 18, 2024 Moneyball, Soccer, and the Gap Between Analytics and the Real World
Sarah Rudd is the co-founder and CEO of the soccer analytics company src | ftbl (It’s pronounced “Source Football.”) Sarah’s problem is this: How do you model a sport as fluid and complex as soccer and translate the analytical insights from the model into meaningful changes on the pitch? This is the third and final episode of our series about people who are working at the frontiers of technology to help elite…
Jul 11, 2024 Using Computer Vision to See What Coaches Can’t
Jimmy Buffi is the CEO and co-founder of Reboot Motion, which uses biomechanics to help athletes in Major League Baseball and the NBA. Jimmy's problem is this: How do you turn data about how professional athletes move into knowledge that helps them perform better? This is the second episode of our series about people who are working at the frontiers of technology to help elite athletes perform better. Music: Let's…
Jul 4, 2024 Scanning Every Muscle to Help Olympians Get Stronger
On the next few episodes of What's Your Problem, Jacob Goldstein is talking with people working at the frontiers of technology to help elite athletes perform better. Today’s guest is Silvia Blemker, a professor of biomedical engineering at the University of Virginia and the co-founder of Springbok Analytics. Silvia's problem is this: How do you combine MRI scans and artificial intelligence to generate new insights…
Jun 27, 2024 Making Blood Vessels in a Factory
Laura Niklason is the co-founder and CEO of Humacyte. Laura's problem is this: How can you use human cells to create blood vessels that surgeons can pull out of a bag and implant into patients? Although still awaiting FDA approval in the U.S., Humacyte's vessels have already been used to treat wounded soldiers in Ukraine. See omnystudio.com/listener for privacy information.
Jun 20, 2024 Creating the Second Atomic Age
As demand for clean energy grows, engineers around the U.S. are working on a new generation of nuclear reactors. These designs reflect how nuclear energy could fit into the power grid – and our lives – in new ways. Yasir Arafat is the Chief Technology Officer at Aalo Atomics. Yasir’s problem is this: How do you mass produce nuclear reactors that are safe, scalable, and cheap? See omnystudio.com/listener for privacy…
Jun 13, 2024 Lifetime Terms, Lifetime Bans, and the Return of Roaring Kitty from Risky Business
This week on Risky Business, Nate and Maria discuss whether Supreme Court Justice Sonia Sotomayor should retire, the perils of sports betting among professional athletes, and what the return of Roaring Kitty means for traditional market analysis. Further Reading: “Sonia Sotomayor Should Retire Now” from The Atlantic “Should Sonia Sotomayor Retire?” from Slate “MLB bans Padres’ Tucupita Marcano permanently for…
Jun 6, 2024 When the Robots Take Over… from Cautionary Tales
Tim Harford is joined by Jacob Goldstein to answer your questions. Does winning the lottery make you unhappy? Is Bitcoin bad for the economy? When does correlation imply causation? And what will Tim and Jacob do when the robot overlords come for their jobs? Enjoy this episode from Cautionary Tales, another Pushkin podcast. See omnystudio.com/listener for privacy information.
May 30, 2024 Making Palm Oil Without Palm Trees
Palm oil is a cheap and remarkably versatile vegetable oil. It’s in a ton of products, from food to cosmetics, detergent, and chewing gum. But producing so much palm oil is really bad for the planet. Shara Ticku is the co-founder and CEO of C16 Biosciences. Shara's problem is this: Can you get yeast to make an oil that is just as useful as palm oil – without clearing land to grow palm trees? See…
May 23, 2024 Fighting Cancer with CRISPR
Last year, the FDA approved a treatment for sickle cell disease using a revolutionary new gene editing technology called CRISPR. Rachel Haurwitz conducted pioneering research on CRISPR as a graduate student. Now she’s the co-founder and CEO of Caribou Biosciences. Rachel's problem is this: How can you improve CRISPR and use it to engineer human immune cells to fight cancer? See omnystudio.com/listener for privacy…
May 16, 2024 How to Start 40 Companies (and Counting)
Robert Langer has co-founded dozens of companies, holds over a thousand patents, and is a pioneering figure in drug delivery and tissue engineering. Robert has solved a lot of problems, and is working on many more with his lab at MIT. But there is one big problem that has stuck with Robert his whole career: How do you get discoveries out of the lab and into the world? See omnystudio.com/listener for privacy…
May 9, 2024 The Cutting Edge of Energy Storage: Rust
Mateo Jaramillo is the co-founder and CEO of Form Energy. Mateo’s problem is this: How do you build batteries that can provide affordable backup power to the grid for days at a time? As it turns out, the basic technology was developed – and then mostly ignored – over 50 years ago. See omnystudio.com/listener for privacy information.
May 2, 2024 The First Pig to Human Kidney Transplant
This March, doctors successfully transplanted a pig kidney into a person for the first time in history. Mike Curtis is the CEO of eGenesis, the company that raised the pig whose kidney was used for the procedure. Mike's problem is this: How do you genetically engineer pigs to provide organs – kidneys, hearts, livers – for people? See omnystudio.com/listener for privacy information.
Apr 25, 2024 Designing a Drone That Delivers
Imagine picking up your phone and ordering something from Walmart. Fifteen minutes later, a drone hovers over your yard, lowers your order down to you, and zips away. Adam Woodworth wants this to be so boring you don't even notice. He’s the CEO of Wing, a drone delivery company. His problem is this: How do you turn a flashy idea like a delivery drone into something as ubiquitous as a shopping cart? See…
Apr 18, 2024 How Do Psychedelics Work?
Psychedelics are going mainstream. The FDA has approved ketamine for certain patients with depression, and may soon approve MDMA for post-traumatic stress disorder (PTSD). But a fundamental question remains unclear: How do psychedelics work? Gul Dolen is a professor of psychology and neuroscience at UC Berkeley. In a series of experiments, Gul has found evidence of a common mechanism that a wide range of…
Apr 11, 2024 Building Boundary-Breaking Balloons
Kai Marshland is the co-founder and chief product officer at WindBorne Systems. Kai's problem is this: How do you build weather balloons that can stay in the air for months at a time, and pair the data gathered by the balloons with AI to make weather forecasts that are way better than anything we have today? See omnystudio.com/listener for privacy information.
Apr 4, 2024 Building a Robot That Can Walk the Walk
Jonathan Hurst is a professor at Oregon State University, and co-founder and chief robot officer at Agility Robotics. Jonathan's problem is this: How do you design a robot that can walk and do useful tasks that companies will pay for? The solution begins with trying to understand how birds walk. See omnystudio.com/listener for privacy information.
Mar 14, 2024 Can Your Phone Tell When You're Getting Sick?
What does sickness sound like? Sometimes it’s obvious, like a cough, sniffle, or stuffy nose. But some conditions cause subtle changes that only a trained ear – or AI – can detect. Dr. Yael Bensoussan is a professor of otolaryngology and the director of the Health Voice Center at the University of South Florida. Her problem is this: How do you build a giant, public database of thousands of voice recordings, and use…
Mar 7, 2024 The High-Stakes Quest to Reinvent Cement
Cement is, almost literally, everywhere. It is extraordinarily useful, which is why humanity makes 4 billion metric tons of it every year. But cement is also extremely carbon intensive to produce. Leah Ellis is the co-founder and CEO of Sublime Systems. Her problem is this: How can you make cement, at scale, without emitting carbon dioxide? See omnystudio.com/listener for privacy information.
Feb 29, 2024 How a Battery-Powered Stove Could Electrify America
Sam D'Amico is the founder and CEO of Impulse Labs, a company that makes induction stoves, with a clever twist. Sam’s problem is this: How do you build an electric cooktop that works just as well as gas, and can be installed without having to rewire the house? The solution that Sam found could eventually help transform not only kitchens, but the way homes draw power from the electrical grid. See…
Feb 22, 2024 3D Printing a Better Rocket
Tim Ellis is the co-founder and CEO of Relativity Space, a company with a unique approach to manufacturing rockets. Tim’s problem is this: How can you use 3D printing to make rockets more efficiently? Eventually, Tim wants to send a rocket – and printer – to Mars to build the first Martian industrial base. See omnystudio.com/listener for privacy information.
Feb 15, 2024 Using AI to Help Doctors Save Lives
Every year in the U.S., tens of thousands of hospital patients die of preventable causes. For many of these patients, warning signs are subtle and easy for doctors to miss. Suchi Saria is the founder and CEO of Bayesian Health, and a professor at Johns Hopkins where she runs a lab focused on machine learning and healthcare. Suchi’s problem is this: How can you use AI to detect when hospital patients are at risk of…
Feb 8, 2024 Making Dam Good Hydropower
Gia Schneider is the co-founder and CEO of Natel Energy, a company that is trying to transform the way hydroelectric power works. Gia’s problem is this: how do you draw hydropower from rivers without damaging the ecosystem? As it turns out, we have a lot to learn from nature’s furriest engineers – beavers. See omnystudio.com/listener for privacy information.
Feb 1, 2024 Using AI to Build Better Robots
Peter Chen is the co-founder and CEO of Covariant. Peter’s problem is this: How do you take the AI breakthroughs of the past decade or so, and make them work in robots? Peter was one of the first employees at OpenAI, the maker of ChatGPT. On the show, he talks about how AI has evolved, and why it's so difficult to teach a robot to fold a towel. See omnystudio.com/listener for privacy information.
Jan 25, 2024 Teaching Computers to See
Fei-Fei Li is a Stanford computer scientist and the former chief scientist of artificial intelligence/machine learning at Google Cloud. When Li entered the field of AI in the 2000s, researchers were making slow progress, optimizing algorithms to incrementally improve outcomes. Li saw that the problem wasn’t the algorithm, but the size of the datasets being used. So she built a massive database of images called…
Jan 18, 2024 Using Oil-Industry Tech to Create Clean Energy
Tim Latimer is the CEO and co-founder of Fervo Energy, a company that is using a new approach to produce carbon-free geothermal energy. Tim and his company are drawing on innovations from the oil and gas industry to expand geothermal energy production to new places like the Utah desert, and maybe one day, to Mars. See omnystudio.com/listener for privacy information.
Dec 28, 2023 Understanding Obesity and Alzheimer’s via Epigenomics
Manolis Kellis is a professor of Computer Science at the Massachusetts Institute of Technology. He works in computational biology, taking giant datasets relating to genetics and health outcomes and tries to understand what’s going on. Manolis’ research focuses on genomics, and a related field called epigenomics. Manolis’ problem is this: What are the cellular mechanisms of a disease? And how can we intervene to…
Dec 21, 2023 Reinventing the Restaurant
After working as a chef for decades, Anthony Strong’s dream came true: He opened his own restaurant. His problem was a classic one: Restaurants are bad businesses. So he set out to open a new kind of restaurant, with a new business model. In this episode, he tells us about how he accomplished that with his latest venture, Pasta Supply Co. in San Francisco. See omnystudio.com/listener for privacy information.
Dec 14, 2023 The Giant Torch That May Help Save the World
Selling hydrogen to make fertilizer is a huge business. It also drives tons of carbon emissions. Rob Hanson, the co-founder and CEO of a company called Monolith is trying to create hydrogen without emissions -- and to do it at scale, at a competitive price. A key tool he’s using: The biggest plasma torch ever built. See omnystudio.com/listener for privacy information.
Dec 7, 2023 Fixing Uber’s Broken Culture
Frances Frei and Anne Morriss are the co-founders of a training and consulting company called The Leadership Consortium. Together they specialize in helping leaders build trust within their companies. They also co-host a podcast called Fixable , which is a TED show produced by Pushkin Industries. Also, Frances is a professor at Harvard Business School. In today’s show, Frances and Anne share the story of their work…
Dec 5, 2023 Murder Brokers from Hot Money: The New Narcos
When a Dutch crime reporter makes an unbelievable discovery, a small-town murder case begins to look like an international assassination plot. Enjoy this episode from Hot Money: The New Narcos , a podcast from Pushkin Industries and the Financial Times. See omnystudio.com/listener for privacy information.
Nov 30, 2023 Using AI for Creative Work
A few weeks ago, Jacob Goldstein sat down with a writer and a composer on a stage in Chicago to talk about artificial intelligence. The conversation, which was part of the Chicago Humanities Festival , aimed to answer a big question: will AI kill creativity? The writer, Stephen Marche, is the author of several nonfiction books and novels. Earlier this year he tried something new: he used AI to help him write a…
Nov 23, 2023 The Little-Known Office With $400 Billion to Fight Climate Change
Jigar Shah is the director of the Loan Programs Office at the U.S. Department of Energy. Last year, as part of the Inflation Reduction Act, Congress allocated hundreds of billions of dollars for Jigar’s office to lend out. The loans are supposed to go to companies that are helping the U.S. economy move away from fossil fuels. That can mean everything from building new nuclear plants to creating a giant hydrogen…
Nov 16, 2023 How AI Solved a Biological Mystery
Pushmeet Kohli is vice president of research at DeepMind, an AI research group that is part of Google. Every protein has a unique shape. And understanding a protein’s shape is key to understanding how proteins work to keep us healthy, and what goes wrong when we get sick. But, for decades, figuring out the shape of a protein was a hard problem that could take years of work. Then Pushmeet and his colleagues built an…
Nov 9, 2023 Making Oxygen on Mars
Forrest Meyen is the co-founder and Chief Strategy Officer of Lunar Outpost, a company that builds machines that go to places like Mars and, if everything goes according to plan, the moon. The company is betting that the private space boom of the past decade will soon go beyond Earth’s orbit to the moon and beyond. See omnystudio.com/listener for privacy information.
Oct 19, 2023 The sold-out chips at the heart of AI
Brannin McBee is the co-founder and Chief Strategy Officer at CoreWeave. A few years ago, he and a few friends started buying hardware to mine cryptocurrency. It turns out, the same hardware -- chips known as GPUs -- is essential for running state-of-the-art AI models. Today, Brannin and his friends have turned their hobby into a company that’s competing against some of the biggest companies in the world to provide…
Oct 12, 2023 Special Episode: The Trial of Sam Bankman-Fried
Sam Bankman-Fried, the former crypto mogul, is on trial for fraud. On today’s show, we talk to Lidia Jean Kott, who is covering the trial for another Pushkin show, about a dramatic day in court. Caroline Ellison, former co-CEO of Alameda Research and Sam Bankman-Fried’s ex-girlfriend, took the stand. She recently pleaded guilty to fraud, and is cooperating with the prosecution. Hear Against the Rules with Michael…
Oct 5, 2023 Getting Yeast to Make Medicine
Christina Smolke is the co-founder and CEO of Antheia. Antheia is a synthetic biology company -- they’re in the business of genetically engineering microorganisms to produce commercial products. Christina’s problem is this: How do you turn yeast cells into tiny factories to create the active ingredients in generic drugs . If Christina and her team solve this problem, they won’t solve the drug shortage problem…
Sep 28, 2023 Could a Robot Make Your Salad?
Stephen Klein is the co-founder and CEO of Hyphen, a company that is developing an automated make line. Stephen's problem is this: How do you make restaurant food from fresh ingredients... cheaper? Chipotle invested in Hyphen, whose automated system could soon be preparing online orders at thousands of Chipotle outlets. See omnystudio.com/listener for privacy information.
Sep 21, 2023 What the Industrial Revolution Teaches Us About the AI Revolution
Simon Johnson is an MIT economist and the co-author of a new book called “Power and Progress: Our Thousand-Year Struggle over Technology and Prosperity”. Simon’s problem is this: How do you create the conditions for technological change to benefit many people, rather than just a powerful few? See omnystudio.com/listener for privacy information.
Sep 14, 2023 Can AI Tutors Help Kids Learn? Khan Academy Thinks So
Sal Khan is the founder and CEO of Khan Academy. Sal’s problem is this: How do you design an AI that can give students the kind of benefits they’d get from working with a human tutor? Earlier this year, Khan Academy launched Khanmigo, an AI tutor built on top of GPT4. The idea is to use AI to give more kids access to one-on-one tutoring, and help human teachers with their work as well. See omnystudio.com/listener…
Sep 11, 2023 Smallpox: Gone but Not Forgotten from Incubation
What can we learn from the centuries-long quest to eradicate smallpox, once the scourge of humanity? And how did it set the stage for all vaccines to come? First we meet Edward Jenner, a doctor in 18th century Britain who learned about the folk practice of “variolation” and found a safer way to inoculate people against smallpox. Then, Donald Hopkins of the Carter Center takes us back to the 1960s in Sierra Leone,…
Sep 7, 2023 Going to the Doctor Sucks. Can AI Make it Better?
Allon Bloch is the co-founder and CEO of K Health. Allon’s problem is this: Can you use AI to make seeing a doctor easier and more helpful? Today, thousands of patients a month are treated through K Health. The company has an AI-based patient interface and it employs about 150 doctors. And K Health has plans to expand beyond primary care -- and they just raised another 50 million dollars to help them get there. See…
Aug 31, 2023 Spotting Wildfires with AI
Sonia Kastner is the founder and CEO of Pano. Sonia’s problem is this: How do you use data and machine learning to mitigate the damage caused by climate change? Pano mounts cameras on remote mountaintop towers, then sends images from the cameras to an AI model trained to spot wildfire smoke. The goal is to alert fire crews early, before the fire spreads. See omnystudio.com/listener for privacy information.
Aug 24, 2023 Is the Era of Free Returns Over?
Amit Sharma is the founder and CEO of Narvar. Narvar works with companies such as Sephora, Lululemon and Home Depot to manage the post-purchase phase of online shopping — tracking, alerts and returns. Around 10 percent of online purchases are returned and every return cuts into retailers’ profits. Amit’s problem is this: consumers have learned to love free returns, but can retailers afford them? See…
Aug 17, 2023 Creative Technology at Pixar
Danielle Feinberg is a Visual Effects Supervisor at Pixar Animation Studios. Danielle’s problem is this: How do you optimize technology so that you can spend more time being creative? Danielle Feinberg has worked at Pixar for 26 years. Earlier in her career, she was the director of photography on movies like Coco and Wall-E. She talks about how new software shapes creative work. See omnystudio.com/listener for…
Aug 10, 2023 How To Make AI Safer & More Reliable
Yaron Singer is the founder and CEO of Robust Intelligence. Yaron’s problem is this: How do you reduce AI’s security and reliability risks? Yaron was a computer science professor at Harvard and worked at Google before starting Robust Intelligence. The company’s software tests AI models and datasets for problems with performance and security. See omnystudio.com/listener for privacy information.
Aug 3, 2023 Quantum Computers Could Change Everything
Chris Monroe is the co-founder and chief scientist of IonQ. Chris’s problem is this: How do you build a quantum computer that will actually work? Quantum computing has the potential to transform fields from drug development to clean energy to cybersecurity, but so far no one has been able to build a quantum computer that can reliably outperform existing computers. Monroe is also a physics professor at Duke…
Jul 27, 2023 The 2023 Unhedged Stock Draft
Seven stocks are powering the market: Alphabet, Amazon, Apple, Meta, Microsoft, Nvidia and Tesla. How will they do in the second half of this year? Ethan Wu hosts as Rob ‘Value This’ Armstrong takes on Elaine ‘The Lex Flex’ Moore. In three rounds they pick their winners for the second half of 2023, and tell us why they chose them. If you enjoyed this preview of the new podcast Unhedged, subscribe to the show now:…
Jul 6, 2023 Predicting Human Health with AI
Charles Fisher is the co-founder and CEO of Unlearn AI. Charles’ problem is this: How do you build an AI model that can predict human health? Charles and his colleagues have built a predictive model of health that is already being used in clinical trials, and might one day be deployed to predict individuals’ health outcomes. See omnystudio.com/listener for privacy information.
Jun 29, 2023 Breastfeeding, Black Market Baby Formula, and Bobbie
Laura Modi is the founder and CEO of Bobbie, a company that makes baby formula and sells it directly to parents. Laura’s problem is this: how do you launch a startup in a highly regulated industry that has pretty much been a duopoly for decades? Part of Laura’s answer is marketing, which raises another question: how do you get people to consider formula despite so much messaging that breastfeeding is better? See…
Jun 22, 2023 Making Immigration Cheaper & Easier
Xiao Wang is the founder of a company called Boundless. Xiao’s problem is this: How do you make it cheaper and easier for people to navigate the U.S. immigration system? Xiao moved to the U.S. from China when he was three years-old. For many years, he took for granted that immigration was slow, complicated, and expensive to navigate. With Boundless, he’s built a platform to help people who try to figure out that…
Jun 15, 2023 The Wind Power Pioneer Still Pushing the Frontier
Henrik Stiesdal got his start in wind power back in the 70s. The price of oil had gone way up, and he wanted to help his parents figure out a cheaper source of electricity for their farm. He went on to help create the modern wind industry. Five decades later, he’s still pushing the frontier. See omnystudio.com/listener for privacy information.
Jun 8, 2023 The Mystery at the Heart of ChatGPT
One of the most amazing things about ChatGPT and other, similar AI models: Nobody really understands what they can do. Not even the people who build them. On today’s show, we talk with Sam Bowman about some of the mysteries at the heart of so-called large language models. Sam is on the faculty at NYU, he runs a research group at the AI company Anthropic and he is the author of the illuminating paper Eight Things to…
Jun 1, 2023 Scrubbing Carbon from the Air
Dan Friedmann is the CEO of Carbon Engineering. The company is at the frontier of a new industry, direct air capture. They just broke ground on a big plant in Texas that will pull carbon dioxide out of the air. Dan’s problem is this: how do you bring the price of direct air capture way down? And how do you convince companies and governments to pay for scrubbing carbon out of the air? See omnystudio.com/listener for…
May 25, 2023 Building a Plane to Help Save the World
Does flying have to be bad for the environment? Val Miftakhov, the founder and CEO of ZeroAvia, doesn’t think so. His company built a plane that’s powered by hydrogen fuel, which produces zero carbon emissions. It had a successful test flight earlier this year and Miftakhov hopes it will be ready for commercial use by 2025. See omnystudio.com/listener for privacy information.
May 18, 2023 The AI that Might Take My Job (And Yours)
Andrew Mason is the founder and CEO of Descript. Descript's software has made editing audio and video much simpler. The company recently received a large investment from OpenAI, the company behind ChatGPT. It's a sign that Descript is moving toward using generative AI to generate words and pictures. What will that mean for the people who currently do that work? See omnystudio.com/listener for privacy information.
May 11, 2023 The Hottest Thing In Energy Storage
Andrew Ponec is co-founder and CEO of the energy storage company Antora Energy. Andrew's problem is this: How can you store renewable energy in a way that is cheap enough and reliable enough for industrial use? He thinks the solution may be storing that energy as heat, in big blocks of graphite. See omnystudio.com/listener for privacy information.
May 4, 2023 Using Bacteria to Dye Jeans
Tammy Hsu and Michelle Zhu are the cofounders of Huue. Their problem is this: how do you get bacteria to produce indigo dye? And how do you do it cheaply and reliably enough to replace the toxic petrochemical process that's currently used to dye billions of pairs of jeans a year? They're working with denim brands to commercialize their bacteria-produced dye. See omnystudio.com/listener for privacy information.
Apr 27, 2023 The Quest for the Factory-Built House
Today's show is about a problem people have been trying to solve for a hundred years: how can we mass produce houses, like we do cars? Listen for a house that looks like a UFO, a giant mobile home boom, and a visit to a 21st-century construction site where workers are putting up a factory-built house. This episode's a co-production with our friends at Planet Money, and a follow-up to last week's interview with the…
Apr 20, 2023 Building Houses Like Tesla Builds Cars
Alexis Rivas is the co-founder and CEO of Cover. His problem is: How do you build houses in a factory, the way you build cars? And how do you do it so they're cheaper and better than a traditionally built house? Cover is following the Tesla model: starting with a high-end product but aiming for the mass market. "Nail it and scale it," he says. See omnystudio.com/listener for privacy information.
Mar 30, 2023 Human Bones, Made In the Lab
Nina Tandon is the co-founder and CEO of a tissue engineering company called EpiBone. Her problem is this: How do you grow custom bone from patients' stem cells, at a price that makes sense? See omnystudio.com/listener for privacy information.
Mar 23, 2023 Tiny Chips, Giant Stakes
Microchips are the most important driver of technological progress in the modern world, and governments are fighting over who gets to make them. Right now, most cutting-edge chips are made in Taiwan, a country that China claims as part of its territory. The U.S. government is fighting to keep semiconductor technology out of China, and spending tens of billions of dollars to get companies to build more chip…
Mar 16, 2023 Problems Solved: Drones, Bananas and Real Estate*
It's our first anniversary and—almost 50 episodes in—Jacob Goldstein checks in with three past guests. Drone delivery guy Keenan Wyrobek thinks he has solved a big problem holding back commercial drone delivery in America. Fruit-ripening maven Katherine Sizov is figuring out bananas. And Glenn Kelman of Redfin has some deep insights from a tough year in the real estate business. *The problems in real estate weren't…
Mar 9, 2023 Faster, Cheaper Drugs with AI
Alice Zhang is the co-founder and CEO of Verge Genomics. Alice's problem is this: How do you use artificial intelligence to drive down the price of developing new drugs? The company is using AI to find new disease mechanisms to target, and to speed up drug development. If using AI can help experimental drugs succeed even a little more often than they do now, it'll be a big win. See omnystudio.com/listener for…
Mar 2, 2023 Creating the Uncrashable Car
When Austin Russell was 17 years old, he founded Luminar Technologies to work on a remote sensing technology called Lidar. Today, Austin is one of the world's youngest self-made billionaires, and Luminar may be on the verge of solving Austin's problem: How do you make Lidar cheap enough and good enough to use in millions of cars? See omnystudio.com/listener for privacy information.
Feb 23, 2023 The Electric Truck that Went Viral on TikTok
Chace Barber is the co-founder of Edison Motors. Chace's problem is this: How do you build electric logging trucks in rural Canada, with money you raised from people who follow you on TikTok? Chace started his career driving logging trucks. He loved the idea of Tesla's electric semi, but when it never arrived, he decided to build his own. If you’d like to keep up with the most recent news from this and other…
Feb 22, 2023 Introducing Other People’s Pockets: Mistress Marley, Financial Dominatrix
Here's a bonus episode of a new show from Pushkin, Other People's Pockets. Have you ever wondered how your friend bought that vacation home or why that colleague of yours makes everyone meticulously split the tab down to the last Diet Coke? Other People's Pockets is a show about other people’s money. Host Maya Lau asks people from all walks of life to get radically transparent about their personal finances in order…
Feb 16, 2023 Running in Recycled Shoes
Caspar Coppetti is the co-founder of On, a company that makes athletic shoes. Caspar's problem is this: How can you sell tens of millions of shoes a year -- and then take them all back, to turn them into new shoes? The company's latest bid to attract new customers? A shoe subscription service. If you’d like to keep up with the most recent news from this and other Pushkin podcasts be sure to subscribe to our email…
Feb 9, 2023 Turning Garbage Into Food
Matt Rogers is the co-founder of Mill. Matt's problem is this: How do you turn garbage into food? Before Mill, Matt co-founded Nest, a smart thermostat company. Now, he wants to take on the garbage in our kitchens with a high tech garbage can that can transform food waste. This is the fourth and last episode of What's Your Problem's four-part series on the future of food. If you’d like to keep up with the most…
Jan 30, 2023 The Fake-Meat Frontier
Jacob Goldstein co-hosts today's show with Dan Pashman, host of The Sporkful . Jacob and Dan eat their way through the history of fake meat -- from Gardenburger hockey pucks, to meatier Impossible burgers. And they get a report from the fake-meat frontier, where scientists are trying to make lab-grown chicken breasts. This is the third episode of What's Your Problem's four-part series on the future of food. If…
Jan 26, 2023 From Impossible Burgers to Fake Steak
Pat Brown is the founder of Impossible Foods. Pat's problem is this: How can you make meat without animals? Pat's goal isn't to make better burgers for vegetarians; he wants to sell to meat eaters. To succeed, he'll have to figure out how to make fake meat that is at least as good -- and as cheap -- as the real thing. This is the second episode of What's Your Problem's four-part series on the future of food. If…
Jan 19, 2023 Small Pizza Shops Want a Bigger Slice
Ilir Sela is the co-founder and CEO of Slice. His problem: How do you bring the technological revolution to thousands of tiny mom and pop pizza shops? Most local pizza shops haven't adapted well to consumers' appetites for online ordering. Ilir's mission is to make sure that the technology powering Big Pizza can also benefit smaller businesses. This is the first episode of What's Your Problem's four-part series on…
Jan 12, 2023 Turning Waves Into Electricity
Tim Mundon is chief technology officer at Oscilla Power. Tim's problem is this: How do you turn waves into electrical power? You can see the power of the ocean in every wave, but the complex churm and swirl of the surf has made it difficult to translate that movement into something useful. Tim Mundon and his colleagues have been working on the problem for more than a decade, and are about to test a new electric…
Dec 29, 2022 From Some of My Best Friends Are: Everything Dope Comes from Chicago
While we’re off celebrating the new year, here’s an episode from another Pushkin show: Some of My Best Friends Are… Hosts Khalil Gibran Muhammad and Ben Austen, two best friends from the South Side of Chicago, invite listeners into unfiltered conversations about growing up together in a deeply-divided country, and navigating that divide today. On this episode, Khalil and Ben find out how Sherman “Dilla” Thomas has…
Dec 15, 2022 Flying on Battery Power
Anders Forslund is the co-founder and CEO of Heart Aerospace. Anders' problem is this: How do you build a commercial airplane that can fly on battery power -- and win the approval of regulators around the world? As other sectors are decarbonizing, emissions from aviation are projected to triple by 2050. This is partly because figuring out how to build a commercial plane that doesn't burn jet fuel is a very, very…
Dec 8, 2022 Bringing Back the American Hoodie
Bayard Winthrop is the founder and CEO of American Giant. Bayard's problem is this: How do you make clothes in America -- and compete in a global economy? Today's show is about the future of American manufacturing. But it is also about something very simple: A sweatshirt made in America. It costs $138, and it is wildly popular. If you’d like to keep up with the most recent news from this and other Pushkin podcasts…
Dec 1, 2022 How to Save the Most Lives
Farzad Mostashari is the co-founder and CEO of Aledade. Farzad's problem is this: How can we pay doctors to keep us healthy, rather than treating us after we get sick? People have been struggling to solve this problem for decades. But for a bunch of reasons you'll hear about on the show, Farzad and his colleagues may be the ones to finally solve it. If you’d like to keep up with the most recent news from this and…
Nov 29, 2022 From Story of the Week with Joel Stein: Billionaires Prepping for the Apocalypse
This bonus episode is from Story of the Week with Joel Stein, a new Pushkin podcast. On Story of the Week, journalist Joel Stein chooses an article that fascinates him, convinces the writer to tell him about it, and then interrupts a good conversation by talking about himself. This episode is about the Medium story “Survival of the Richest” by Douglas Rushkoff. In it, Rushkoff discovers a whole industry catering to…
Nov 24, 2022 The Investors Everybody Ignored
Sallie Krawcheck is the founder and CEO of Ellevest, an investment firm for women that has over $1 billion in assets under management. In her career in finance, Sallie was often one of the only women in the room. But even she had to be convinced that women would benefit from an investment firm created just for them. If you’d like to keep up with the most recent news from this and other Pushkin podcasts be sure to…
Nov 16, 2022 Sam Bankman-Fried Revisited
In May of this year, we interviewed Sam Bankman-Fried, the young billionaire philanthropist who started the crypto exchange FTX. Last week, in a matter of a few days, FTX collapsed and filed for bankruptcy, and Sam resigned. It's unclear if customers or investors will ever get their money back. In light of the news, we are replaying the episode -- and trying to figure out what to make of everything Sam told us…
Nov 10, 2022 Machiavelli's Tips for Getting Ahead at Work
Stacey Vanek Smith is the author of "Machiavelli for Women: Defend Your Worth, Grow Your Ambition, and Win the Workplace." Her problem is this: How do women get ahead in a workplace that is stacked against them? Stacey is my old co-host from Planet Money. Today, she brings us strategies from the 16th-century writer for how to thrive in an unjust world. This episode was recorded in front of a live audience. If you’d…
Nov 3, 2022 Google's Journey to the Edge of Search
Cathy Edwards is vice president and GM of Search at Google. Cathy's problem is this: how do you teach computers to tell people what they want to know, even if they don't know how to ask? Google's last leap: Moving from search results based on keywords to search results based on concepts. The next step: Figuring out how to let people search using not just words, but combinations of words and images. If you’d like to…
Oct 27, 2022 Paying People to Turn Off the Fridge
Matt Duesterberg is co-founder and president of OhmConnect. Matt's problem: How do you build a business around getting people to save energy? Not all that much. And not all the time. But just enough, at just the right time. OhmConnect is paying customers to reduce their household's energy usage at times of high demand. The company is a window into the bizarre world of energy markets -- and human behavior. If you’d…
Oct 20, 2022 Turning Writers into Publishers
Chris Best is co-founder and CEO of Substack. Chris's problem: How do you help writers make a living from a thousand true fans? Substack is a company that helps writers send subscription-based email newsletters. Which, as Chris says, is a very simple idea, built on top of some very grandiose beliefs about culture and ideas and commerce. If you’d like to keep up with the most recent news from this and other Pushkin…
Oct 13, 2022 Shopify: The Business That Helps Build Businesses
Harley Finkelstein is the president of Shopify. He may love entrepreneurship more than anyone we've ever met. Harley’s problem: How do you aggregate the power of millions of small businesses to help them compete against giants? If you’d like to keep up with the most recent news from this and other Pushkin podcasts be sure to subscribe to our email list . See omnystudio.com/listener for privacy information.
Oct 6, 2022 Putting Carbon Back Into the Ground
Shaun Kinetic is co-founder and chief scientist of Charm Industrial. Shaun’s problem: How do you put billions of tons of carbon back into the ground? Charm Industrial is fighting climate change in a giant but kind of overlooked corner of the economy: Agriculture. Fields of corn and wheat and soybeans absorb billions of tons of carbon dioxide from the air every year. But then, once the crops are harvested, the…
Sep 29, 2022 Patching Together a Quilting Empire
Al Doan is the executive chairman of the Missouri Star Quilt company. Al's problem is this: How do you combine low tech and high tech to turn a niche hobby into a wildly successful company? In 2008, Al and his siblings helped their mom open a quilt shop in Hamilton, Missouri. Now, the business has grown to over 100 million a year in revenue and Jenny Doan, Al's mom, has become the YouTube quilting star. If you’d…
Sep 8, 2022 Revealing How Much Health Care Really Costs
Chris Severn is the co-founder and CEO of Turquoise Health. Chris's problem is this: How do you figure out the real price trip of a trip to the hospital -- before it happens? People have been trying to solve this problem for decades, but there's a good reason to think that this time is different. In 2019, the federal government issued a new rule that said insurers and hospitals have to publish their prices. Not…
Sep 1, 2022 Saving the World with Poop
Mariana Matus is co-founder and CEO of Biobot Analytics. Her problem: How do you turn sewage into useful public health data? When she and her co-founder launched the company, wastewater epidemiology was a niche field nobody paid much attention to. The Covid pandemic changed that. Studying wastewater has become one of the most important tools for tracking the pandemic. And Mariana's company, Biobot Analytics, has…
Aug 25, 2022 Building an Empire on Free Code
Matt Mullenweg co-created WordPress, the open-source software that powers more than 40% of all the websites in the world. He's also the founder of a for-profit company called Automattic. Matt's problem is this: How do you build a multibillion-dollar company on top of software that your competitors can use for free? If you’d like to keep up with the most recent news from this and other Pushkin podcasts be sure to…
Aug 18, 2022 Selling Billions of Crickets a Year
Mohammed Ashour is the co-founder and CEO of Aspire Food Group. The company just built the biggest cricket factory in the history of the world. His problem: How do you sell billions of bugs a year? If you’d like to keep up with the most recent news from this and other Pushkin podcasts be sure to subscribe to our email list . See omnystudio.com/listener for privacy information.
Aug 15, 2022 From Patented: Inventing the Wheeled Suitcase
We put man on the moon before we invented the wheeled suitcase. Why did it take so long? Find out in this episode of Patented: History of Inventions, where host Dallas Campbell is joined by expert Katrine Marçal, whose research has revealed an intriguing hidden chapter in the invention story of rolling luggage. If you're interested in the stories behind the world's greatest inventions — from the mighty steam train…
Aug 11, 2022 How the Nerds Conquered the NBA
Rajiv Maheswaran is the co-founder and president of Second Spectrum. Rajiv and his company figured out how to turn raw sports data into useful information for coaches. Today, the company works with basketball and soccer teams in the NBA, the Premier League and Major League Soccer. Rajiv's problem: How do you teach a computer to understand sports? If you’d like to keep up with the most recent news from this and…
Aug 4, 2022 The Trick to Flying Cheap
David Neeleman has founded five airlines, including JetBlue. He recently launched a new airline, called Breeze. His problem: How do you use technology to bring down the cost of airfares? He's been working on that problem for decades -- from inventing ticketless travel in the 1980s, to building a 21st century airline where customers never need to call customer service to ask for help. If you’d like to keep up with…
Jul 28, 2022 Beer Without the Buzz
Bill Shufelt is the founder and CEO of Athletic Brewing Company. His problem: How do you turn non-alcoholic beer from a punchline into something people drink all the time? If you’d like to keep up with the most recent news from this and other Pushkin podcasts be sure to subscribe to our email list . See omnystudio.com/listener for privacy information.
Jul 21, 2022 John Green Tests the Limits of YouTube
John Green is the author of The Fault in Our Stars and six other novels. He also co-founded a company that makes educational videos that have been viewed billions of times. John's problem: How do you make videos that actually help people make it through college? If you’d like to keep up with the most recent news from this and other Pushkin podcasts be sure to subscribe to our email list . See…
Jul 14, 2022 Taking Bets on the Future
Luana Lopes Lara is the co-founder of Kalshi, an exchange that lets ordinary people bet on everything from the path of inflation to what bills Congress will pass by the end of the year. Her problem: How to you build a market like the New York Stock Exchange that lets people bet on real-world events? If you’d like to keep up with the most recent news from this and other Pushkin podcasts be sure to subscribe to our…
Jul 13, 2022 From Unsung Science with David Pogue: The Man Who Stopped the Spammers
A special preview of the podcast, Unsung Science with David Pogue from CBS News. Journalist and author David Pogue finds the untold creation stories behind the most mind-blowing advances in science and tech—and hears from the characters involved—from their first inspiration to the times they almost gave up. This episode looks at the bad guys who used software bots to sign up for millions of fake email accounts—for…
Jul 7, 2022 Building Bespoke Weather Forecasts
Shimon Elkabetz is the founder and CEO of Tomorrow.io. His problem: How do you build a weather forecasting company from scratch? The company already sells weather intelligence to companies like JetBlue, Uber and the NFL. Their next move: Send the first private constellation of weather satellites to space (without running out of money). If you’d like to keep up with the most recent news from this and other Pushkin…

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About What's Your Problem?

Episodes

Every Cell in Your Body Has a Clock

How a Bad Boss Kickstarted Silicon Valley... from Business History

Solving the Trust Problem in AI Shopping

Can a Robot Build Better, Cheaper Houses?

Did AI Write This?

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